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  • Carbimazole 5mg Tablets 100's

Carbimazole 5mg Tablets 100's

kes1,120
Description
Carbimazole is an antithyroid agent that decreases the uptake and concentration of inorganic iodine by thyroid, it also reduces the formation of di-iodotyrosine and thyroxine. Once converted to its active form of methimazole, it prevents the thyroid peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T3 and T4. Hyperthyroidism means that the thyroid gland is overactive and makes too much thyroid hormone. Thyroid hormone helps to control energy levels and growth. Too much thyroid hormone can make it difficult for your child to gain weight and grow well, and may make them feel tired and anxious. Carbimazole works by decreasing the amount of thyroid hormone released from the thyroid gland.
How to use
Posology and method of administration: Carbimazole should only be administered if hyperthyroidism has been confirmed by laboratory tests.
Older people: No special dosage regimen is required, but care should be taken to observe the contraindications and warnings as it has been reported that the risk of a fatal outcome to neutrophil dyscrasia may be greater in the elderly (aged 65 or over).
Paediatric population: Use in children and adolescents (3 to 17 years of age). The usual initial daily dose is 15 mg per day adjusted according to response. Use in children (2 years of age and under).
Safety and efficacy of carbimazole in children below 2 years of age have not been evaluated systematically. Use of carbimazole in children below 2 years of age is therefore not recommended.
Adults: The initial dose is in the range 20 mg to 60 mg, taken as two to three divided doses. The dose should be titrated against thyroid function until the patient is euthyroid in order to reduce the risk of over-treatment and resultant hypothyroidism.Subsequent therapy may then be administered in one of two ways.
Maintenance regimen: Final dosage is usually in the range 5 mg to 15 mg per day, which may be taken as a single daily dose. Therapy should be continued for at least six months and up to 18 months. Serial thyroid function monitoring is recommended, together with appropriate dosage modification in order to maintain a euthyroid state.
Precautions
Contraindications: Hypersensitivity to the active substance or to any of the excipients listed.• Serious, pre-existing haematological conditions.• Severe hepatic insufficiency.• Patients with a history of acute pancreatitis after administration of carbimazole or its active metabolite thiamazole.