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Linamide 25, a thalidomide analogue, is an immunomodulatory agent w/ antiangiogenic and antineoplastic property. It inhibits proinflammatory cytokines secretion, increases interleukin-2 and interferon-γ secretion, and increases cytolytic T-cell and natural killer cell response. It also inhibits the growth of myeloma cells by inducing cell cycle arrest and cell death. Linamide 25 is a thalidomide analogue used for the treatment of patients with: Multiple myeloma (MM), in combination with dexamethasone MM, as maintenance following autologous hematopoietic stem cell transplantation (auto-HSCT) Transfusion-dependent anemia due to low- or intermediate-1-risk myelodysplastic syndromes (MDS) associated with a deletion 5q abnormality with or without additional cytogenetic abnormalities Mantle cell lymphoma (MCL) whose disease has relapsed or progressed after two prior therapies, one of which included bortezomib
Each capsule contains lenalidomide as the active ingredient and the following inactive ingredients:Â lactose anhydrous, microcrystalline cellulose, croscarmellose sodium, and magnesium stearate.
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