Esomeprazole+itopride is used to treat acidity, gastro-oesophageal reflux disease (GERD), stomach ulcers (peptic ulcers, gastric ulcers due to H pylori), heartburn symptoms and Zollinger Ellison syndrome. Gastroesophageal reflux disease occurs when stomach acid frequently flows back into the food pipe (oesophagus). Peptic ulcers are sores that develop on the inner lining of the intestine and stomach. A gastric ulcer occurs mainly due to a bacteria known as H pylori, which irritates and weakens the upper protective layer or mucous of the stomach, leading to sores and ulcers. Esomeprazole+itopride is a combination medicine used to treat acidity, gastro-oesophageal reflux disease (GERD), stomach ulcer and heartburn. Esomeprazole+itopride is a combination of two drugs: Esomeprazole and Itopride. Esomeprazole belongs to a group of medicines called proton pump inhibitors, whereas itopride belongs to a group of medicines called prokinetic agents. Esomeprazole works by blocking the action of an enzyme called the gastric proton pump, responsible for the production of stomach acid. Itopride works by accelerating the gastric emptying time, thereby increasing the movement of the food pipe, intestine and stomach. Besides this, Itopride also has anti-emetic action, which prevents the symptoms of nausea and vomiting. Together, Esomeprazole+itopride helps in preventing acid reflux, thereby providing relief from hyperacidity, ulcers and heartburn.